I am a much bigger student of history & more intelligent than most here.
The next big ISIS type rising & global war will be due to this Palestine thing - There will be a point when there will be breaking point when Israel could be attacked by multiple nations similar to Arab-Israel war due to Palestine area (whatever small part of PLO is left) being taken over completely by settlements. The Arab nations are much stronger militarily than what they once were.
Assad is in a stronger position than his father? The king of Jordan will turn his back on the west?
The only country bordering Israel that is conceivably threatening is Egypt, but considering the country is basically a river, all it takes is destroying the Aswan Dam should push come to shove.