If it's her stance on issues, Donald Trump is slightly more liberal than her and thus closest. Ted Cruz is the most conservative candidate running and is therefore least like her.
There are issues where Trump is more liberal than her, but that doesn't make him closer to her.
Hillary Clinton and Donald Trump both have supported socialized medicine, higher taxes on the wealthy and companies that "outsource," the pro-choice position, a pathway to legal status for folks here illegally, domestic partnership rights for same-sex couples, protectionist trade policies, and gun control.
Another similarity - both don't claim to hold those positions today because they flip-flop for political reasons.