Am I misreading this - how would that prevent the Democrat from winning if he/she had 270+ EVs?
It wouldn't. The goal would be to prevent both Trump and the Democrat from getting to 270 by going all in on a few key states.
If Trump is the candidate, that throws a bunch states into the Democrats' column that it would be very hard for an independent Republican to take, even with a concentrated focus. You need to appeal to:
Heartland states (Ohio, Indiana, Missouri)
Western swing states (Colorado, Nevada, Arizona)
The Nouveau Mid-Atlantic (Virginia, North Carolina)
and... oh, yeah: FLORIDA.
What candidate is going to do that? Know of any Latino generals/admirals from Ohio?