You made it sound like a GOP shoo-in. You can't take the Obama-McCain election as a future forecaster for it is still a very Democratic district and there is a deep Dem bench. The 2008 election was an anomaly and Hillary Clinton would have likely won that district by at least 10 points.
Honestly, why would a top-tier Democrat even want to run for the seat? Pennsylvania is losing seats in 2012, and if a Democrat wins this, they're guaranteed to be redistricted into oblivion.
Not to even mention the standard 2010 line about Democrats being likely to get slaughtered.