How is this anti-science? Climate Change is basic science which every intelligent educated person should understand.
Economics is also a basic subject every intelligent person should understand, even if they disagree on whether it is a science. Whether or not this pipeline is built will not affect how much fossil fuel consumers use, so the impact on climate change is effectively nil, and probably positive since less energy is needed to transport oil by pipeline than the alternatives.
Geology is more clearly a science, and it is safer to have a pipeline cross a major river at a static lake rather than where the river is actually flowing. From the standpoint of geology, crossing the Missouri at the northern tip of Lake Oahe makes the most sense of the alternatives.