I'd honestly be a bit nervous about what's been going down in WV paying a visit to Iowa over the next several cycles. Not sold on it, but a bit nervous...
It's possible, the return back to normal after the 80's farming crisis, but in reality Iowa is more like Minnesota or Wisconsin. Also there is no coal industry, so no war on coal, and having the first caucus every 4 years will mean that both parties will always have a big infrastructure there.
But it does stick out like a sore thumb with way too much rural D support and few logical reasons for it. Also, there is something of a new farming crisis developing, which also fits with unusually weak R support in their solid Plains states (Ashford, Heitkamp, KS being close).