Her populist rhetoric would play well in the Rust Belt cities I would say, but she is very much not right for the suburbs of this region. Suburban Minneapolis, Detroit, Chicago, and Cleveland swung hard for Obama and just may stay there for Clinton. I can't see them doing so for Warren as they are generally not attracted to the extremes of either party. I don't necessarily think that that would hurt her that greatly, and I think she actually is a decent fit for the region.
Here's how I think she would fare off the bat vs Generic R:
90% = safe
50% = likely
30% = lean
