Should states be allowed to leave the USA?

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The real problem here is that, when there is a conflict with a government, the ultimate question is military might.

In practice, the question would be whether the secessionists actually want to go to war over this, and unless there is something seriously bad going on, the answer will be "no."

However, I would personally be in favor of allowing Scottish-type independence referendums in US states. How I would vote in such a referendum depends on the circumstances.