McConnell is one of the most unpopular Senators in the country and he did worse in 2008 and 2014 than McCain and Romney, in the former case coming close to losing. The Democrats do seem increasingly toxic in Kentucky, and a Hillary Clinton-type Democrat is bound to get wiped out in Kentucky. But a Joe Manchin type Democrat could have a shot at beating McConnell.
Since when are wins by over 15 points considered "close to losing." This is pure partisan how that lacks substantive support. Majority Leader McConnell will remain a senator as long as he wants for many reasons