Yes. The GOP as we've known it is dead.
The Dems will be a free trade, pro immigration party going forward and the Republicans will be protectionist and nativist. It's amazing it's taken this long to change giving that the GOP base doesn't give a damn about trade and immigration reform despite voting for it for decades.
The southwest moves more towards the Democrats (Nevada, Colorado, New Mexico, and Arizona) while the Midwest and Rust-Belt goes more towards the GOP (Pennsylvania, Michigan, Ohio, Iowa, and maybe Wisconsin).
It's the only realignment possible this time.
There's basically no chance Wisconsin goes GOP. They hate Trump.