Possibly the Nazis might have progressed to the point of being able to build a crude reactor, but even had they developed bombs equivalent to Fat Man or Little Boy, they didn't have a delivery system able to carry such heavy bombs. The best they could have done would have been to use it to as basically an atomic mine, hiding a bomb that would be blown up once the enemy had taken the area. Maybe detonate it in Berlin itself as part of the Nero Decree.
You couldn't stick one on a V2?
A nuke would have been too heavy of a payload for a V2 to carry and even if that wasn't a problem I think it would be really difficult to design a bomb that wouldn't blow up prematurely due to the V2's supersonic speeds