This is actually a district that Democrats would be wise to contest in a special election. Yeah, the district went for Bush by 61%-39% in 2004, but that is the exact same margin that John Kerry won MA-05 by and Republicans seem to be contesting that.
Also, as recently as 1998, this district voted for Mark Hodges and Fritz Hollings.
"Contest" just means run a candidate - of course the Democrats will run a candidate. The era of letting safe districts slide seems to be over nationally. The Republicans haven't a hope of winning MA-05, and the Democrats haven't a hope of winning SC-01.