No!
To secede over one election is so idiotic. Then they'll want to come back in when the Democrats are back in power.
I have a feeling that if California seceded that they would wind up one of the States of Mexico.
California has a larger GDP than Mexico.
I wonder what the effect on the US economy would be if California seceded?
Probably worse than anyone can imagine. The U.S. wouldn't be a leader in hi-tech (there are a lot of hi tech companies based in Seattle, Boston, Austin and a few other cities, but the vast majority is in the Bay Area). The entertainment industry would be greatly affected (movies are one of the main exports of the U.S. economy). Agriculture too, since California is a large producer. Also, California is America's link to the Pacific, which means that trade with Asian countries would be affected as well, so say goodbye to cheap cellphones. I'm betting that if California leaves the U.S., Hawaii would follow.