In 2000? I don't think McCain and Santorum didn't start going at it until fairly recently. Even then, McCain came in to help Santorum in 2006 and they even worked on legislation together.
Truth be told, I don't know how much McCain even cares about Santorum. Unfortunately, it seemed like Rick just had some silly grudge (what it was really about, who knows) and decided to act ridiculous about it. If he was ever offered the running mate spot, he would have set aside the issue and accepted. He was supportive of McCain through the General election campaign this year.
I don't understand how Rick Santorum can dislike McCain so much yet support Specter the turncoat over Toomey.