Meg Whitman at Treasury.
But Treasury is a too important and powerful post to give to someone from the other party.
Something like Secretary of Commerce is more plausible. Remember Obama wanted to nominate Judd Gregg for the post and Gregg initially accepted.
Most of the Obama presidency has had a Republican SecDef.
Interestingly, since 1997, there were only two Democratic Secretaries of Defense
William Cohen (1997-2001)Donald Rumsfeld (2001-2006)Robert Gates (2006-2011)Leon Panetta (2011-2013)Chuck Hagel (2013-2015)Ashton Carter (2015-)
