Yes, I don't see Issa surviving, considering the unpopularity of Trump, both broadly and in this district, and the likelihood of Democrats targeting this seat much more strongly in 2018 than they did in 2016. In fact, I tend to think it's pretty much lost for the GOP bar Issa either retiring or getting primaried (the latter I don't see happening, the former might be a possibility).
Also, CA-Gov has always been Issa's dream; he's far from a perfect candidate but he'd definitely be a better option than Peter friggin Thiel. If I were him, I'd go for that.
Hopeful both him and Rohrbacher lose.
If Democrats are serious about the whole "Russia is a threat to national security" thing, they should go after Rohrabacher
hard.