No, though President Grant shouldn't be on it either. Put someone like Coolidge on there.
I agree they should put Reagan on the fifty, and create a new one like $75 with Coolidge on it.
Really, they should start printing bills over $100 again. A dollar now is worth much less than it was in 1969, such that someone actually using a larger bill isn't so implausible.
I wouldn't hold my breath for larger bills any time soon. Large transactions are seldom paid for in cash, the organized crime concerns that took large bills out of circulation circa 1969 still exist, and counterfeiting concerns would be a horrendous nightmare.
Besides, by the time there would be an inflationary need for a higher-than-$100 bill, we'll be on an entirely electronic monetary system anyway.