No, she won't. The only way she would lose reelection is if she murdered somebody. Her district is that Democratic.
She'd still win.
No, she won't. "Dollar Bill" Jefferson lost reelection in 2008 despite the fact that his district was extremely Democratic. In this scenario, she would either get primaried or lose the general election.
I think we need to be more specific about her hypothetical victim here. For example, she might get a record high percentage of the vote if she murdered Cheney.
Cheney would shoot her if she ever tried to do that. I mean, he shot that lawyer, and that lawyer didn't even do anything bad to Cheney.