Why did Ohio's Republican Congressional Districts lose so much population? Was it because of the loss of manufacturing jobs?
OH-1 is based around inner-city Cincinnati and most of the loss was people moving further and further out into the suburbs. This is an ancestral Republican seat that has become more Democratic due to the Republicans fleeing the city and was swingy by the end of the decade.
OH-6 is a formerly coal mining area along the Ohio River with a few rust belt towns that continue to bleed jobs. This is an ancestrally Democratic seat, originally drawn as a Democratic pack in 2002, that the Republicans just took over after the 2010 wave.
OH-5 is the scenario you're talking about more than anything else. It consists of a mix between farmland and heavily industrial towns across Northwest Ohio, neither of which are growing.