I did find that Dearborn, Michigan had the most Muslims, by percent, among US cities, and in that city, according to Zogby, Muslims claim not to feel isolated. In fact, more generally, Zogby states that "Unlike Muslims in Europe, American Muslims do not tend to feel marginalized..." Pew research has similar findings.
That's mostly because Muslim immigrants to the United States are much richer than European Muslims.
And why are they richer?
Countries of origin, I thought?
EDIT: The vast majority of Muslim-Americans I've actually
known were extremely secular, but that's selection bias as I don't normally talk to people that are really religious. One of my best friends is an ex-Muslim atheist and first generation immigrant from Syria, and I've heard her say things about Islam that are more negative than most ultra-right wing Islamophobes.