Who would be the best choice to replace Biden and why?

[Lincoln Republican]

Reid, because he took the fall for Obama in lying about Romney, and because Reid is as old as dirt.

Come to think of it, Reid is dirt.

[Lincoln Republican]

Presidents who have replaced their Vice Presidents or have had their Vice Presidents replaced for them

Thomas Jefferson-Aaron Burr, George Clinton
James Madison-George Clinton, Elbridge Gerry
Andrew Jackson-John C. Calhoun, Martin Van Buren
Abraham Lincoln-Hannibal Hamlin, Andrew Johnson.  
(Tough luck for Hamlin.  He would have become President)
Ulysses S. Grant-Schuyler Colfax, Henry Wilson
William McKinley-Garret Hobart (died in office), Theodore Roosevelt
Franklin D. Roosevelt-John Nance Garner (first two FDR terms), Henry Wallace (third FDR term), Harry Truman
(Tough luck for Wallace.  He would have become President)
Richard Nixon-Spiro Agnew (resigned), Gerald Ford
(Tough luck for Agnew.  If he wasn't a crook he would have become President)