But we wouldn't have to worry about state-to-state conflicts anymore, and nobody could seriously say "it's not America's responsibility to look after them" anymore. Trade and immigration policies would be obsolete. The military would have to be transformed. But what would new majorities of voters want to change about the way U.S. government operated and what its responsibilities should and shouldn't be?
There would probably be a Constitutional amendment to get rid of Article I, Section 9, after which immigration and trade-related issues would cease to be obsolete. No way people would accept global free trade and immigration.