I still think that if Progressives could someone who is at least competitive in a Iowa Caucus, that invincibility goes out the window, just like 2008. As for the General Election... She's the underdog against Ryan (who almost certainly isn't running) and Walker (who probably is), it's a coin toss against Bush, Rubio, and Portman, she'd be the favorite against Cruz and Paul, and a mortal lock against Perry. (Am I missing anybody?)
If Ryan was such a great candidate, he would've been able to carry his home state in 2012.
People don't vote for Vice-President
The base of the Republican Party that called John McCain a RINO/establishment/moderate etc. would disagree with you per 2008, you betcha.