Realistically, could anyone beat Hillary in a primary?

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Perhaps, but it will be harder than 2008. 2008 required all of the following 3 for her to lose
Iraq war vote and hawkishness on Iran
Mark Penn running a terrible campaign, ignoring caucuses, race baiting.
Obama being a good candidate

But the good news is that she managed to blow an almost sure thing in 2008, so could do it again.

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A majority of Americans are becoming hawks -- about ISIS.

A majority of Americans don't support arming "moderate" rebels who include ISIS.

[○∙◄☻¥tπ[╪AV┼cVê└]

It has to be another women like Kirsten Gillibrand or Amy Klobuchar possibly even Tammy Baldwin. I also think Deval Patrick or Cory Booker would give her a good run someone like O'Malley just doesn't stand a chance.

I'd be crazy if we could only get a woman nominated.

Booker is just as bad as Hillary.  Baldwin, Patrick, or O'Malley would be fine.