If I had to choose just one, Rob Portman --> Chris Redfern (Portman's not bad, but he's not great either; + Redfern's plain awesome)
Among others:
Jeff Sessions --> Our hero Victor Sanchez Williams
Mitch McConnell --> Alison Lundergan Grimes
John Cornyn --> Julian Castro
John Thune --> Rick Weiland
Thad Cochran --> Connie Moran
John McCain --> Gabrielle Giffords
Johnny Isakson --> Jason Carter
Pat Roberts --> Kelly Kultala
Jim Inhofe --> Any LGBT Oklahoman he's offended over the years
James Lankford --> Brad Henry
Marco Rubio --> Debbie Wasserman Schultz
Ron Johnson --> Ron Kind
Kelly Ayotte --> Maggie Hassan
Mike Enzi --> Cathy Connolly
Steve Daines --> Steve Bullock
Pat Toomey --> Joe Sestak
Lisa Murkowski --> Ethan Berkowitz
Chuck Grassley --> Tom Vilsack
Mark Pryor --> Vic Snyder
Joe Manchin --> Nick Casey
Heidi Heitkamp --> Ed Schultz
Sherrod Brown with Ed FitzGerald (ok, I'm joking).
You probably wouldn't want Brown as Senator, either.
Boccieri or Portune might be more in line with your views.