Without negative effects is indeed what I was thinking. Where would the tax cuts be, which ones would be eliminated altogether, and where would we cut spending?
If your only goal is to not negatively impact the economy, then they can really be anywhere. If you want to maximize growth, the best tax to cut would be the corporate tax, since the US has one of the highest rates in the world and corporate taxation just makes little sense in general (tax costs can just be passed on to consumers and workers via higher prices and lower wages). Payroll taxes are also pretty bad but they're directly tied to certain programs so reducing them would have to depend on what spending you're cutting. Personally I'd try to reduce a broad range of taxes but taxes on personal and business income would be my top priority.
As for the first areas I'd cut, see my previous post in this thread. I'd also cut Education, since the DoE's primary function is to take in money and then distribute it to State governments on the condition they do x, y, and z. There's no evidence whatsoever that this has a positive impact on educational outcomes.