Yeah, it'll have as much effect as "you didn't build that". Remember when the GOP staged their entire convention around that flop of an attack? That was adorable.
This is obviously way worse than "you didn't build that". Thankfully for her, she said it two years out, so it won't have much effect.
How? It's the exact same thing. An out of context quote "proving" that they hate business and capitalism or whatever. I still remember all the Republicans cheering that "you didn't build that" sealed Romney's victory as Obama revealed his anti-business communist roots.
I'm not sure it will have less effect though, since you can't go below zero.