By the way: Which Republican would help make this "possible"?
Imagine a scenario in which two Republicans, say Ted Cruz and Chris Christie, fight in a long drawn out primary battle. Ted Cruz is in the lead, but then Christie pulls through with a deal with a dropped out candidate who had a handful of delegates (the establishment, frightened to death of a Cruz candidacy, expedites this behind the scenes). That candidate becomes the vice president and Cruz is out for blood, vowing to take the fight to the general election.
Hillary easily dispatches challenges from Webb and Sanders, who each get roughly 15% of the vote in Iowa and New Hampshire before dropping out.
Cruz v. Chistie v. Clinton is a blowout. Cruz and Christie spend the debates ripping each other apart out of spite, while Clinton is free to espouse a populist message unhindered.
Nationwide Result:
Clinton: 56% (531 EVs)
Christie: 24% (0 EVs)
Cruz: 20% (6 EVs)
Wyoming:
Clinton: 35%
Cruz: 34%
Christie: 31%