Even if Kirk, Johnson, and Toomey are all taken out, you guys would still need one more seat, which would result in having to go after a secondary challenge like Ayotte, who will likely survive, and Burr, who probably will also
Iowa, North Carolina, New Hampshire, Ohio, Florida are all potential contested GOP-held seats in 2016. It's way too early to rule any of them out.
Arizona and Iowa are both potential Democratic pickups should the incumbent, octogenarian Republican Senators retire. Senator Portman (Ohio) is at risk of a primary challenge for showing support for same-sex marriage. Burr (North Carolina), Blunt (Missouri), and Rubio (Florida) have achieved little and are vulnerable. Maybe even Vitter (Louisiana) might have trouble if someone dredges up the prostitution scandal. How strong is Isakson in Georgia? Should Michelle Nunn decide to run again, she has experience in a surprisingly-close race.
Much will depend upon how current Republican Senators show themselves. If they make very reactionary statements, then the Koch fronts will be delighted -- but will the voters?