Imagine a universe where the Native Americans had smallpox and spread it to the European visitors. 95% of Europeans wouldve died over the ensuing century and the Native Americans would be the most populous group of people on earth... And the English would have a sh**tty wind blasted mountain in Scotland to call home.
Lolno. Europeans aren't even close.
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I don't think that it's unreasonable to assume that any diseases that Native Americans introduced to Europeans, assuming that those diseases were as devastating as the ones that Europeans introduced to Native Americans, wouldn't have had any trouble spreading along trade routes to infect every group of people in the Old World, sans perhaps the more remote inhabitants of Siberia and the Khoisan of southwest Africa.