Hood will be reelected. He should run for Senator in 2018.
And lose? What for? He, probably, wants to be undefeated in his political career. And 2018 will be a midterm year, we all know what usually happens there. Wicker is a solid conservative, but will not make McDaniel blunders.
Even with (unlikely) McDaniel blunders, it's still Mississippi we're talking about, not Missouri, not even Indiana, where such blunders made a difference.
There's a difference between running as Democrat for state office in Republican state, and running for Congress.