I'm fairly confident that the Democrats will hold Nevada and Colorado and then have a clean sweep of all 8 competitive seats in the east.
Dem Pickups: IA, IL, WI, OH, PA, NH, NC, FL
I agree if Republicans nominate a nutjob a la Ted Cruz (one can dream), the Democratic nominee (Hillary or otherwise) runs a strong campaign, and Grassley retires in Iowa (he isn't going anywhere otherwise). The last 2 cycles have shown that once it's clear who will win overall (Dems in 2012, GOP in 2014), they tend to run up the score in the last week or so and overperform expectations (Most saw Dems breaking even as best case scenario in 2012 and they gained 2, not many expected GOP to topple Hagan and very nearly topple Shaheen and Warner in 2014), so should Dems win a blowout Presidentially it will likely come with big Senate gains.