Winning two of Florida, Ohio, and Pennsylvania is clearly enough for Hillary Clinton even without Colorado and Virginia. The Republican must win two of the three to have anywhere near an even change of winning the Presidency; all three seals it for the Republican.
So it's 'choose how to lose' for Republicans.
Clinton will win CO, NV, NH and PA and IA for 272, but OHiO is a must win state because along with NM, it has correctly picked the popular vote winner and electoral vote winner since 1976, and NM is part of the 272 firewall as well.