The one comparison for 2000 vs. 2008 is dumb because that was her official Senate picture, and was clearly airbrushed.
Not only that, the 2000 picture is as unflattering as possible for anyone of any age -- bad lighting creating shadows that emphasize lines and wrinkles; she's speaking, so her facial muscles are creating lines that aren't otherwise there; and the camera is looking upward at her, which is considered the worst angle to photograph from.
There's no way to win at this if you're a woman. If you get plastic surgery to stave off the aging process, people laugh at you for trying to look younger than you are. If you let yourself age naturally, people just say, "Damn, she looks so old!"
If you think there isn't a double standard, ask why no one ever brings up John Kerry's facelift/dermal fillers. I mean seriously, the man might as well be wearing a wooden mask.