Opinion polls have consistently indicated that the North East is the most pro-remain region in England outside London, whatever that's worth (probably not all that much). As I feel I should make a prediction now that I've posted I'll say London, the three Celtic nations/provinces, the North East and North West will vote for Remain. The South East will be 50-50 and the others will vote to leave. The East Midlands and Eastern will be the strongest leave regions.
The North East gets a lot of regeneration money from the EU as a relatively poor area of England, and its economy is heavily influenced by Nissan and other Japanese car manufacturers.