There are the givens (MN, WI, IA, IL, IN, MI, OH) and there is Missouri which I consider belonging both to the Midwest and the South.
Neither the St Louis metro (1.897 M in MO in 2010) nor the Kansas City metro (1.085 M in MO) are southern cities. Together they make up half of state's population (49.8% in 2010). Add in the northern rural areas and it's more than half. The southern region of MO is probably no more than a third.
Lots of states have part of their population in a different region. If one must place a state it seems most reasonable to place it in the region where the majority of its population resides.