YES!/Yes/No
If you're voting yes on 2, you're effectively negating 3.
Issue 2 is a complete farce concocted by the Republicans specifically to confuse the electorate into invalidating marijuana legalization even if it does pass, in addition to making future citizen's initiatives harder to qualify for passage. It's just another way for Republicans to restrict voters' power.
Does Issue 2 invalidate Issue 1?
Would Issue 2 invalidate an amendment that just straight-up legalized mary-jane without a monopoly clause?
Have you read Issue 2? What are your sources?
It appears that Issue 2
may invalidate Issue 3, which would be a shame if the voters approve Issue 3 despite its clear flaws, but there is likely to be a legal challenge to that anyway and it would generate incentive to craft a weed legalization bill without the monopoly clause.
1: No
2: No
3: Yes
(Republican who is in favor of Republicans being elected and marijuana being legalized)
If Republicans are forced to actually make themselves more appealing to voters instead of rigging things with gerrymandering, they'd be better off in the end.