Anywhere and everywhere is a bit of a stretch. A 4 lane median separated rural highway is about the safest road you can have... and with wide shoulders it can also accommodate cyclists and pedestrians (though those are rare on rural highways)
I think the biggest thing is that you want traffic moving... not stopped... but also not moving too quickly. And you want a faster transit alternative. The problem with American cities is often even with these traffic calming road diets, you are not offering an alternative. Now the buses have to drive slower as well. And dedicated bus lanes are only feasible in the "bus"iest of areas (see what I did there)