She's really been hurting his campaign, which was already experiencing turbulence before her exploits (i.e plagiarism, nude pictures, lesbianism).
I can't recall the last time a candidate's wife gave the candidate so much trouble. Michelle Obama, Laura Bush, Ann Romney, Cindy McCain --- none of them aroused so much negative attention. In fact, most of them helped the candidate, especially Michelle Obama and Cindy McCain.
Which is amazing, considering Laura Bush is the only candidate spouse to my knowledge who has actually killed someone.