Considering that Democrats are likely to take the Senate on January 3, 2017 (current polling suggests 5 Democratic gains for a 51-49 advantage),
A net 4 gains as current polling suggests they'll lose Nevada, tho if Titus had entered the race, she probably would be leading now in a rematch of her 2010 defeat in the House race to Heck, thus giving her the additional savor of revenge. Unless Castro manages to pull it out, Titus is going to be facing a strong set of what might have beens from both herself and others had she taken the riskier route.
That said, I think Garland is likely to be approved by the lame duck, so it's not impossible Clinton won't get a chance to nominate someone until 2020.