Bush lost his home state: Connecticut
1804: Charles Cotesworth Pinckney of South Carolina lost home state and election to Thomas Jefferson.
1808: Charles Cotesworth Pinckney of South Carolina lost home state and election to James Madison.
1816: Rufus King of New York lost home state and election to James Monroe.
1840: Martin Van Buren of New York incumbent President lost home state and election to William Henry Harrison.
1844: James Polk of Tennessee lost home state to Henry Clay, but won the election.
1852: Winfield Scott of New Jersey lost home state and election to Franklin Pierce.
1856: John Fremont of California lost home state and election to James Buchanan.
1856: Millard Fillmore of New York former President lost home state to John Fremont, who lost election to James Buchanan.
1860: Stephen Douglas of Illinois lost home state and election to Abraham Lincoln, who was also from Illinois. (either way, a candidate would lose his home state, of course)
1860: John Breckinridge of Kentucky lost home state to John Bell, who lost the election to Abraham Lincoln.
1864: George McClellan of New York lost home state and election to Abraham Lincoln.
1872: Horace Greeley of New York lost home state and election to Ulysses S. Grant.
1880: Winfield Hancock of Pennsylvania lost home state and election to James Garfield.
1888: Grover Cleveland of New York incumbent President lost home state and election to Benjamin Harrison.
1892: Benjamin Harrison of Indiana incumbent President lost home state and election to former President Grover Cleveland.
1900: William Jennings Bryan of Nebraska lost home state and election to William McKinley.
1904: Alton Parker of New York lost home state and election to Theodore Roosevelt, who was also from New York (either way, a candidate would lose his home state).
1912: Theodore Roosevelt of New York former President lost home state and election to Woodrow Wilson.
1912: William Howard Taft of Ohio incumbent President lost home state and election to Woodrow Wilson.
1916: Woodrow Wilson of New Jersey incumbent President lost home state to Charles Hughes, but won the election.
1920: James Cox of Ohio lost home state and election to Warren Harding, who was also from Ohio (either way, a candidate would lose his home state).
1924: John William Davis of West Virginia lost home state and election to Calvin Coolidge.
1928: Alfred Smith of New York lost home state and election to Herbert Hoover.
1932: Herbert Hoover of California incumbent President lost home state and election to Franklin Roosevelt.
1936: Alfred Landon of Kansas lost home state and election to Franklin Roosevelt.
1940: Wendell Willkie of New York lost home state and election to Franklin Roosevelt, who was also from New York (either way, a candidate would lose his home state).
1944: Thomas Dewey of New York lost home state and election to Franklin Roosevelt, who was also from New York (either way, a candidate would lose his home state).
1952: Adlai Stevenson of Illinois lost home state and election to Dwight Eisenhower.
1956: Adlai Stevenson of Illinois lost home state and election to Dwight Eisenhower. (How sad is that-- not only did he lose again to Ike, but he lost his home state twice, too)
1968: Richard Nixon of New York (he moved there after having lost his bid to be CA's governor) lost home state to Hubert Humphrey, but won the election.
1972: George McGovern of South Dakota lost home state and election to Richard Nixon.
2000: Al Gore of Tennessee lost home state and election to George W. Bush.