All the people immediately saying he has no chance are totally ignoring the fact that they said the exact thing about Donald Trump....but look who the president elect is.
Now, do I think it is probably he wins, no, but there is always a chance.
... Massachusetts is not America.
I think Silent Cal's point was that nothing is 100% certain in politics. Which is true, but the fact remains that Senate races are getting more polarzed, not less, and Massachusetts is getting more Democratic, not less (part of the 2016 trend was probably Romney, but even with that in mind there's no massive Republican trend here).