If 2022 is a Trump midterm, with 6 more years of demographic movement, the Senate is practically likely D. PA+NC+GA+FL+AZ+AK should be very doable by then. Even in a worst case scenario where they only win Clinton states in 2018, that should be enough.
I'm a bit confused by this analysis. The GOP gains all 10 Trump states but loses Nevada, which brings them to a 61-39 seat majority. In order for 6 seats to be enough to flip the Senate in 2022, Democrats need to gain 5-6 seats in 2020. I think that's vaguely possible (Colorado, North Carolina, Iowa, Georgia, Alaska, Montana, maybe Maine) but only if Trump loses the presidency in an absolute landslide. If that happens, 2022 is unlikely to be good year for Democrats even if the map is amazing.
2022 is certainly possible, but very unlikely in a "worst case scenario" in 2018.