If 2022 is a Trump midterm, with 6 more years of demographic movement, the Senate is practically likely D. PA+NC+GA+FL+AZ+AK should be very doable by then. Even in a worst case scenario where they only win Clinton states in 2018, that should be enough.
Yes. But - probably not sooner. In 2018 Senate map is atroccious for Democrats and Trump (most likely) will be not too unpopular (it takes time to get there). In 2020 states like AZ and GA will still be at least Lean R. By 2022 - possible.
Trump is already unpopular it's very and in my opinion likely he will be toxic in 2018