-Not to nominate a criminal
-Not to insult millions of Americans
-Not to nominate someone with baggage and a high unfavorability rating
-Not to pick a nominee who will suppress the Progressive wing of the party
That is just a few of them.
Basically this and some other things mentioned in this thread. I'd also add that their obsession with social issues is really hurting them in the rural and suburban areas. While I don't think they will move to the right when it comes to social issues, they would do best if they focused on economic issues.