Interstate highways that pass through 2 major cities with the same name

[SingingAnalyst]

I-77 passes through Charleston, WV and Charleston, SC.

You can define "major" however you wish.

[True Federalist (진정한 연방 주의자)]

While as a metropolis, Buffalo, WY hardly qualifies as major, since it is where I-25 terminates at I-90, I'd say that for Interstate purposes it qualifies as major and Buffalo, NY is also on I-90.