I'm gonna get a lot of hate for this, but, Robert Byrd.
Actually a pretty popular opinion, but it is kind of ironic given how "liberally" you accuse others of racism, LOL.
Anyway, in no particular order:
Everett Dirksen (R-IL)
Prescott Bush (R-CT)
Charles Sumner (R-MA)
Henry Cabot Lodge (R-MA)
Edward Brooke (R-MA)
Sam Nunn (D-GA)
Robert Stafford (R-VT)
Margaret Chase Smith (R-ME)
Olympia Snowe (R-ME)
Irving Ives (R-NY)
Jacob Collamer (R-VT)
Probably forgetting some.
I feel like a fake republican for forgetting to list these amazing people. Great choices, RINO Tom.
Trivia: Everett Dirksen was the father-in-law of another Senator who's appeared in this thread, Howard Baker. (And more trivia: Baker's second marriage was to Sen. Nancy Landon Kassebaum, so he almost had two famous Republican fathers-in-law, but for the fact that Alf Landon died years before Baker and Kassebaum married.)