"Multiple sources in Western New York politics have confirmed that there is a strong possibility that" Rep. Tom Reynolds (R–NY) "will not run for a sixth term next year," according to The Capitol.
"Rumors of a potential Reynolds departure... have been flying around political circles in Buffalo and Niagara Falls for months, though Reynolds spokesman L.D. Platt denies the rumors and says the congressman will run again."
CQ has a good backgrounder on the district which is Republican Favored. The Albany Project has more information on the rumors.
http://politicalwire.com/archives/2007/11/17/reynolds_retirement_rumors_pick_up_in_ny26.html