Absolutely. Most of us would never see the candidates or hear anything about their plans that pertain to us. The only places anyone would campaign are the ten biggest cities.
LOL. That would be such a terrible campaign strategy even FDR wouldn't win with it in 1932. Combine the top fifty metropolitan areas in the country and you still don't even have half of the population.
(For the record, MSA #50 is Rochester, NY.)
^^^
Take a look at Gubernatorial and Senatorial elections. Candidates go all over the state - not just the big cities. A nationwide popular vote election would be no different.