Louisiana has elected a female governor though.
Only because its voters had to choose between a woman and an Indian-American.
I don't think she'll lose just because of that, but psychologically voters, especially in parts of the United States that have a very old male-dominated political culture, are more hesitant to elect women in executive positions. I could be a bit biased [or informed?] because I just completed a 15 page (20 with bibliography haha) research paper into this last week.
Here are the states that have elected had female governors. Notice where the red and purple ones are (not anywhere near the South). But hey, always easy to break these rules, especially with Sanford's backing.
While those maps don't prove that SC won't elect a woman governor, it supports the fact some cultures (usually rural, conservative and Southern, but it is interesting that Penn. is so low) are less comfortable with women leaders and such cultures even discourage women from running for any elected office.
Also, states having female Governors who succeeded their husbands (Wallace, and I think another in Texas early in the 20th century) is a special case and does not support whether such states are comfortable with women leaders.